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Boston Red Sox starting pitcher Eduardo Rodriguez celebrates after striking out St. Louis Cardinals' Randal Grichuk to end the sixth inning of a baseball game Tuesday, May 16, 2017, in St. Louis. (AP Photo/Jeff Roberson)

ST. LOUIS (AP) — Mookie Betts homered and drove in two runs, Jackie Bradley Jr. also went deep and the Boston Red Sox beat the St. Louis Cardinals 6-3 on Tuesday night to take the opener of a two-game interleague series.

Bradley had two of Boston's six hits, and starter Eduardo Rodriguez (2-1) allowed three runs and five hits over six innings. Rodriguez walked two, struck out five and threw a season-high 110 pitches.

St. Louis made three errors and lost for just the second time in 10 games. Lance Lynn (4-2) gave up four runs, two earned, and three hits in six innings, striking out four and walking one.

Betts began the game with his seventh homer and 10th career leadoff shot, tying Jacoby Ellsbury for the franchise record. Bradley added a solo homer in the second for a 2-0 lead.

Craig Kimbrel pitched a scoreless ninth for his 12th save in 13 chances.

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